RAF Typhoon FGR4s have conducted a mission with French warplanes in a combined operation on an underground arms cache in Syria operated by the IS group, according to the UK's MoD.
The location, pinpointed through intelligence, was assessed as storing arms and explosives, the statement said, and was located in hills just to the north of Palmyra in central Syria.
"The RAF jets utilized Paveway IV guided bombs to strike a several access tunnels leading to the facility... preliminary assessments suggest the target was engaged successfully," the MoD said.
There was no sign of any civilian casualties in the strike on Saturday evening and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager refuelling tanker.
Daesh - alternatively referred to as ISIS - established militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This operation demonstrates British leadership, and commitment to operate in unison with our partners, to stamp out any resurgence of IS and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister remarked.
RAF aircraft have carried out patrols over Syria to "prevent any attempted resurgence" of Islamic State subsequent to its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of British forces who took part in this operation for their expertise and their valour," the Defence Secretary commented. "Including them were numerous British troops on duty over Christmas and New Year. This operation, to eliminate dangerous terrorists who threaten our security, highlights how British military are prepared to act, all year round, ensuring Britain's security at home and strong abroad."
During December, the United States armed forces conducted what it termed a "large-scale strike" targeting Daesh sites in Syria, after an assault claimed the lives of two American soldiers and a local interpreter in Palmyra.
The UN estimates IS still has between 5,000 and 7,000 combatants in both countries.
